Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium
Xuan Wang‐Kan, Giovanny Rodriguez Blanco, Andrew D. Southam, Catherine Winder, Warwick B. Dunn, Alasdair Ivens, Laura J. V. Piddock
Abstract
Typhimurium. Molecules that inhibit multidrug efflux potentiate the activity of old, licensed, and new antibiotics. The additional significance of our research is in providing data about the identity of potential natural substrates of AcrB in both species. Data on these will facilitate the discovery of, and/or could be chemically modified to become, new efflux inhibitors.
Topics & Concepts
EffluxSalmonella entericaEscherichia coliVirulenceMultiple drug resistanceBiologyBacteriaMicrobiologyMultidrug Resistance-Associated ProteinsAntibiotic resistanceMutantSalmonellaEnterobacteriaceaeDrug resistanceAntibioticsBiochemistryATP-binding cassette transporterGeneticsGeneTransporterAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsSalmonella and Campylobacter epidemiology