<i>In vitro</i>inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes
Shangchen Xu, Fengqing Zhang, Dali Chen, Keren Su, Zhang Li, Rui Jiang
Abstract
study indicated that GAA has the potential to result in drug-drug interactions with other drugs metabolized by CYP3A4, 2D6, and 2E1. Further clinical studies are needed for the identification of this interaction.
Topics & Concepts
Cytochrome P450In vitroEnzymePharmacologyChemistryInhibitory postsynaptic potentialBiochemistryBiologyEndocrinologyPharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects of Natural Compounds