New sulfonamide-tethered coumarin derivatives as potential DNA gyrase inhibitors: Design, synthesis, antimicrobial evaluation, and in silico study
Heba M. Abo‐Salem, Eman AboBakr Ali, Shaima A. El-Mowafi, Mohamed S. Abdel‐Aziz, Eslam R. El‐Sawy, Hayam A. Abd El Salam
Topics & Concepts
ChemistryCoumarinSulfonamideDNA gyraseIn silicoAntimicrobialCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryEscherichia coliGeneSynthesis and Biological EvaluationSynthesis and biological activityEnzyme function and inhibition