The regulatory roles of small nucleolar RNAs within their host locus
Étienne Fafard-Couture, Stéphane Labialle, Michelle S. Scott
Abstract
with their intron to regulate the expression of their host gene. We also explore the ever-growing diversity of longer host-derived snoRNA extensions and their functional impact across the transcriptome. Finally, we discuss the role of snoRNA duplications into forging these new layers of snoRNA-mediated regulation, as well as their involvement in the genomic imprinting of their host locus.
Topics & Concepts
Small nucleolar RNABiologyGeneticsGeneLocus (genetics)IntronTranscriptomeRNANon-coding RNALong non-coding RNARegulation of gene expressionGene expressionComputational biologyRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing