A copper iodide-catalyzed coupling reaction of benzofuran-3(2<i>H</i>)-ones with amines: an approach to α-ketoamides
Rongxiang Chen, Jia Ruo-ling, Wenbo Li, Wei Zhao, Kai‐Kai Wang, Zhan‐Yong Wang, Xueji Ma, Wei Dai, Aili Sun
Abstract
A CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines has been well established for the direct synthesis of α-ketoamides. This process involves C-O bond cleavage and C[double bond, length as m-dash]O/C-N bond formation. Mechanism studies indicated that this α-ketoamide formation reaction may involve a free radical process.
Topics & Concepts
ChemistryBenzofuranCatalysisBond cleavageCopperCoupling reactionIodideMedicinal chemistryCleavage (geology)Coupling (piping)Polymer chemistryPhotochemistryStereochemistryOrganic chemistryGeotechnical engineeringMechanical engineeringFracture (geology)EngineeringCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions