High cytotoxic and apoptotic effects of platinum(<scp>ii</scp>) complexes bearing the 4-acridinol ligand
Tai-Ming Shao, Zu‐Zhuang Wei, Xiaoling Luo, Qi‐Pin Qin, Ming‐Xiong Tan, Jia-Jing Zeng, Chun-Jie Liang, Hong Liang
Abstract
4-Acridinol platinum(<sc>ii</sc>) complex <bold>PtA</bold> induces SK-OV-3/DDP cell apoptosis that is mediated by the mitochondrial dysfunction pathway.
Topics & Concepts
ChemistryCytotoxic T cellPlatinumApoptosisLigand (biochemistry)Bearing (navigation)CytotoxicityStereochemistryReceptorBiochemistryIn vitroCartographyCatalysisGeographyMetal complexes synthesis and propertiesSynthesis and biological activityBioactive Compounds and Antitumor Agents