Bacterial Lectin-Targeting Glycoconjugates for Selective Elimination of Pathogenic Bacteria
Ji Young Hyun, Chang‐Hee Lee, Hosoowi Lee, Woo‐Dong Jang, Injae Shin
Abstract
Herein we report a strategy to eradicate pathogenic bacteria selectively, which utilizes bacterial lectin-targeting glycoconjugates that contain an epitope or a photosensitizer to promote antibody-dependent cellular cytotoxicity (ADCC) or photodynamic therapy (PDT), respectively. Our results show that death promoted by using the designed synthetic glycoconjugates coupled with ADCC or PDT takes place selectively in pathogenic bacteria expressing lectins on their surfaces.
Topics & Concepts
GlycoconjugateLectinAntibody-dependent cell-mediated cytotoxicityPathogenic bacteriaEpitopePhotosensitizerBacteriaMicrobiologyCytotoxicityGlycocalyxPhototoxicityPhotodynamic therapyAntibodyChemistryBiologyBiochemistryImmunologyIn vitroGeneticsOrganic chemistryCancer Research and TreatmentsPhotodynamic Therapy Research StudiesBacteriophages and microbial interactions