Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer’s disease
Suresh B. Rangasamy, Malabendu Jana, Sridevi Dasarathi, Madhuchhanda Kundu, Kalipada Pahan
Topics & Concepts
HippocampusIn vivoNeuroprotectionPeroxisome proliferator-activated receptorADAM10NeuroscienceInternal medicineDownregulation and upregulationEndocrinologyMedicineReceptorPsychologyBiologyBiochemistryMetalloproteinaseDisintegrinMatrix metalloproteinaseBiotechnologyGeneAlzheimer's disease research and treatmentsTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms