Mechanism of praziquantel action at a parasitic flatworm ion channel
Sang-Kyu Park, Lukas Friedrich, Nawal A. Yahya, Claudia M. Rohr, Evgeny G. Chulkov, David Maillard, Friedrich Rippmann, Thomas Spangenberg, Jonathan S. Marchant
Abstract
, confers PZQ sensitivity. After decades of clinical use, the molecular basis of PZQ action at a druggable TRP channel is resolved.
Topics & Concepts
Fasciola hepaticaPraziquantelDruggabilityBiologyIon channelFasciolaNiclosamideSchistosoma mansoniEmetineFlatwormPharmacologySchistosomiasisImmunologyBiochemistryReceptorHelminthsZoologyGeneParasites and Host InteractionsParasite Biology and Host InteractionsHelminth infection and control