GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis
Xuezhi Yang, Wankang Zhang, Ziqing Zhu, Wei Zhao, Lingli Luo, Luping Wang, Yingjie Zhao, Yan Chang, Wei Wei
Topics & Concepts
SuccinylationRheumatoid arthritisPhosphorylationGlycolysisMacrophagePKM2MedicineArthritisChemistryPyruvate kinaseBiochemistryCancer researchImmunologyInternal medicineGeneMetabolismIn vitroAcetylationBiochemical and Molecular ResearchPeptidase Inhibition and AnalysisRNA modifications and cancer