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Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model

Şefika Pınar Şenol, Meryem Temiz-Reşitoğlu, Demet Sinem Güden, Ayse Nihal Sari, Seyhan Şahan-Fırat, Bahar Tunçtan

2021Neurochemical Research18 citationsDOI

Topics & Concepts

BexarotenePharmacologyTLR4AgonistHyperalgesiaNeuroprotectionChemistryInflammationNociceptionLipopolysaccharideRetinoid X receptorSignal transductionReceptorEndocrinologyMedicineInternal medicineNuclear receptorBiochemistryGeneTranscription factorPharmacological Effects of Natural CompoundsPeroxisome Proliferator-Activated ReceptorsRetinoids in leukemia and cellular processes
Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model | Litcius