Eosinophil-associated microinflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early-life adversity
Shaoqi Duan, Takashi Kondo, Hiroto Miwa, Yanjing Yang, Shenglan Wang, Hirosato Kanda, Yoko Kogure, Nobuko Imamura, Tadahiro Fujimura, Tomoaki Kono, Masashi Fukushima, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Satoshi Yamamoto, Koichi Noguchi, Yi Dai
Abstract
We showed for the first time that neonatal MS stress-induced FD rats undergo gastroduodenal eosinophil-associated microinflammation in adulthood. Suppression of microinflammation attenuated gastric hypersensitivity in MS rats. These findings established a functional link between microinflammation and gastric hypersensitivity, which may provide a potential clue for the clinical treatment of FD.
Topics & Concepts
EosinophilMedicineGastroduodenal ulcerGastrointestinal tractImmunologyInternal medicineGastroenterologyPeptic ulcerAsthmaEosinophilic EsophagitisGastrointestinal motility and disordersGastroesophageal reflux and treatments