1,25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence.
Wanxin Qiao, Shuxiang Yu, Hai‐Jian Sun, Lulu Chen, Rong Wang, Xuan Wu, David Goltzman, Dengshun Miao
Abstract
D insufficiency accelerates age-related bone loss by increasing oxidative stress and DNA damage, inducing bone cell senescence and SASP, and subsequently inhibiting osteoblastic bone formation while stimulating osteoclastic bone resorption.
Topics & Concepts
EndocrinologyInternal medicineOxidative stressSenescenceDNA damageBone resorptionVitamin D and neurologyBone mineralBone marrowChemistryBiologyMedicineOsteoporosisDNABiochemistryVitamin D Research StudiesTelomeres, Telomerase, and SenescenceBone Metabolism and Diseases