Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
Balaji Virassamy, Franco Caramia, Peter Savas, Sneha Sant, Jianan Wang, Susan N. Christo, Ann Byrne, Kylie Clarke, Emmaline Brown, Zhi L. Teo, Bianca von Scheidt, David Freestone, Luke C. Gandolfo, Karsten E. Weber, Julia Teply‐Szymanski, Ran Li, Stephen J. Luen, Carsten Denkert, Sibylle Loibl, Olivia Lucas, Charles Swanton, Terence P. Speed, Phillip K. Darcy, Paul J. Neeson, Laura K. Mackay, Sherene Loi
Abstract
gene signature extracted from tumor-free tissue was significantly associated with improved clinical outcomes in TNBC patients treated with checkpoint inhibitors.
Topics & Concepts
Cytotoxic T cellCD8Immune checkpointImmune systemCancer researchBiologyPhenotypeBreast cancerTriple-negative breast cancerImmunologyImmunityCancerImmunotherapyGeneIn vitroGeneticsCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesT-cell and B-cell Immunology