Glycosuria Alters Uropathogenic Escherichia coli Global Gene Expression and Virulence
Md. Jahirul Islam, Kamal Bagale, Preeti P. John, Zachary Kurtz, Ritwij Kulkarni
Abstract
Uropathogenic Escherichia coli (UPEC) is an important causative agent of urinary tract infections in diabetic humans. We examined the effects of in vitro exposure to glycosuria (presence of glucose in urine) on the virulence and gene expression by UPEC. Our results show that glycosuria rapidly (in 2 h) alters UPEC gene expression, induces biofilm formation, and suppresses type 1 piliation. These results offer novel insights into the pathogenesis of UPEC in the urinary tract.
Topics & Concepts
VirulenceEscherichia coliMicrobiologyGlycosuriaBiologyBiofilmUrinary systemGenePathogenesisBacteriaIn vitroVirulence factorDiabetes mellitusGeneticsImmunologyEndocrinologyEscherichia coli research studiesGut microbiota and healthUrinary Tract Infections Management