Magnesium Contact Ions Stabilize the Tertiary Structure of Transfer RNA: Electrostatics Mapped by Two-Dimensional Infrared Spectra and Theoretical Simulations
Jakob Schauss, Achintya Kundu, Benjamin P. Fingerhut, Thomas Elsaesser
Abstract
excess, the number of contact ion pairs per tRNA saturates around 6 and weakly interacting ions prevail. Our results suggest a predominance of contact ion pairs over long-range coupling of the ion atmosphere and the biomolecule in defining and stabilizing the tertiary structure of tRNA.
Topics & Concepts
ElectrostaticsInfraredMagnesiumIonInfrared spectroscopySpectral lineChemical physicsChemistryMolecular physicsMaterials sciencePhysicsOpticsPhysical chemistryQuantum mechanicsOrganic chemistryRNA and protein synthesis mechanismsFuel Cells and Related MaterialsDNA and Nucleic Acid Chemistry