Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells
Kelli L. VanDussen, Lisa J. Funkhouser-Jones, Marianna E. Akey, Deborah A. Schaefer, Kevin Ackman, Michael W. Riggs, Thaddeus S. Stappenbeck, L. David Sibley
Abstract
Cryptosporidium sp. occupies a unique intracellular niche that exposes the parasite to both host cell contents and the intestinal lumen, including metabolites from the diet and produced by the microbiota. Both dietary and microbial products change over the course of early development and could contribute to the changes seen in susceptibility to cryptosporidiosis in humans and mice.
Topics & Concepts
Cryptosporidium parvumBiologyMicrobiologyMetabolomeCryptosporidiumPathogenGut floraImmune systemIntracellular parasiteMetaboliteFecesImmunologyBiochemistryParasitic Infections and DiagnosticsAmoebic Infections and TreatmentsClostridium difficile and Clostridium perfringens research