Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N′-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction
Dhulfiqar Ali Abed, Ahmed R. Ali, Sumi Lee, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu
Topics & Concepts
ChemistryNaphthaleneScaffoldStereochemistryCombinatorial chemistryProtein–protein interactionKEAP1Medicinal chemistryBiochemistryOrganic chemistryTranscription factorMedicineBiomedical engineeringGeneGenomics, phytochemicals, and oxidative stressSynthesis and Biological EvaluationFree Radicals and Antioxidants