Fosmanogepix Therapy of Disseminated <i>Fusarium</i> Infection
Drew J. Winston, Patricia A. Young, Haran T. Schlamm, Gary J. Schiller
Abstract
Invasive Fusarium infections cause high mortality. Fosmanogepix, a first-in-class antifungal agent, has potent activity against Fusarium. A patient with acute leukemia with invasive fusariosis, probably involving the central nervous system and caused by Fusarium lactis resistant to currently available antifungal agents, was cured of her infection with fosmanogepix. Fosmanogepix was well tolerated.
Topics & Concepts
FusariosisFusariumMedicineAntifungalVoriconazoleMicrobiologyDermatologyBiologyBotanyAntifungal resistance and susceptibilityFungal Infections and StudiesFungal Biology and Applications