Germline variants associated with toxicity to immune checkpoint blockade
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H. Nassar, Ziad Bakouny, Talal El Zarif, Renée Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew Schmidt, Chris Labaki, Biagio Ricciuti, Joao V. Alessi, David A. Braun, Sachet A. Shukla, Tanya E. Keenan, Eliezer M. Van Allen, Mark M. Awad, Michael P. Manos, Osama E. Rahma, Leyre Zubiri, Alexandra–Chloé Villani, Benjamin P. Fairfax, Christian Hammer, Zia Khan, Kerry L. Reynolds, Yevgeniy R. Semenov, Deborah Schrag, Kenneth L. Kehl, Matthew L. Freedman, Toni K. Choueiri, Alexander Gusev
Topics & Concepts
GermlineImmune checkpointImmune systemHazard ratioMedicineGenome-wide association studyAdverse effectBlockadeGermline mutationInternal medicineOncologyBiologyGenotypeMutationImmunologyGeneticsImmunotherapySingle-nucleotide polymorphismGeneReceptorConfidence intervalCancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsImmune Cell Function and Interaction