Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo
Hongyu Zhang, Changlong Hao, Aihua Qu, Maozhong Sun, Liguang Xu, Chuanlai Xu, Hua Kuang
Abstract
Abstract The accumulation and deposition of β‐amyloid (Aβ) plaques in the brain is considered a potential pathogenic mechanism underlying Alzheimer's disease (AD). Chiral l/d ‐Fe x Cu y Se nanoparticles (NPs) were fabricated that interfer with the self‐assembly of Aβ42 monomers and trigger the Aβ42 fibrils in dense structures to become looser monomers under 808 nm near‐infrared (NIR) illumination. d ‐Fe x Cu y Se NPs have a much higher affinity for Aβ42 fibrils than l ‐Fe x Cu y Se NPs and chiral Cu 2− x Se NPs. The chiral Fe x Cu y Se NPs also generate more reactive oxygen species (ROS) than chiral Cu 2− x Se NPs under NIR‐light irradiation. In living MN9D cells, d ‐NPs attenuate the adhesion of Aβ42 to membranes and neuron loss after NIR treatment within 10 min without the photothermal effect. In‐vivo experiments showed that d ‐Fe x Cu y Se NPs provide an efficient protection against neuronal damage induced by the deposition of Aβ42 and alleviate symptoms in a mouse model of AD, leading to the recovery of cognitive competence.