Osmotic pump tablets with solid dispersions synergized by hydrophilic polymers and mesoporous silica improve in vitro/in vivo performance of cilostazol
Shiming Zhang, Yuanhang Sun, Le Zhou, Zhujun Jiang, Xinggang Yang, Yu Feng
Topics & Concepts
BioavailabilityDissolutionMaterials scienceAmorphous solidSupersaturationPolymerDispersion (optics)Dosage formChemical engineeringMesoporous silicaDissolution testingChromatographyIn vivoIVIVCChemistryMesoporous materialPharmacologyOrganic chemistryEthyl celluloseComposite materialMedicinePhysicsEngineeringOpticsBiotechnologyBiologyCatalysisDrug Solubulity and Delivery SystemsAnalytical Methods in PharmaceuticalsAnalytical Chemistry and Chromatography