Molecular function of Krüppel-like factor 7 in biology
Yi Mao, Yuechan Chen, Zhiwei Zhang
Abstract
<p indent="0mm">Krüppel-like factor 7 ( <italic>KLF7</italic>), also named ubiquitous <italic>KLF</italic> ( <italic>UKLF</italic>) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals. There are few reports on KLF7 among KLFs; however, an increasing number of reports are demonstrating that KLF7 plays an important role in development and diseases. Genetic studies have shown that the DNA polymorphisms of <italic>KLF7</italic> are associated with obesity, type 2 diabetes mellitus (T2DM), lachrymal/salivary gland lesions, and mental development in some populations of humans, and the DNA methylation of <italic>KLF7</italic> is associated with the development of diffuse gastric cancer. In addition, biological function studies have shown that KLF7 regulates the development of the nervous system, adipose tissue, muscle tissue and corneal epithelium as well as the preservation of pluripotent stem cells. Additionally, disease-related studies have shown that KLF7 is involved in the development or progression of T2DM, hematologic diseases, lung cancer, gastric cancer, squamous cell carcinoma of the head and neck, pancreatic ductal adenocarcinoma, glioma, advanced high-grade serous ovarian cancer and osteosarcoma. This review provides research progress on the genetic association, molecular properties and biological function of KLF7, and it may shed light on the understanding of the molecular function of KLF7 in biology and the molecular mechanisms of some diseases.