Stimuli-responsive nanozymes for wound healing: From design strategies to therapeutic advances
Yu Wei, Wanchun You, Haiqing Li, Jiawen Chen, Ziyi Tang, Yawen Luo, Wantong Xiao, Qianwen Yang, Meixin Feng, Li Li, Menglei Wang
Abstract
Nanozymes, which mimic the activity of natural enzymes, have demonstrated significant advantages in wound healing. Stimuli-responsive nanozymes, a novel design type developed recently, are capable of on-demand targeted release, catalytic activity modulation, and facilitating synergistic therapeutic strategies. Such advancements further enhance the safety and efficacy of nanozyme-based treatments. Although numerous studies have reported their high efficiency in promoting wound healing, there remains a lack of updated review literature on this topic. This paper starts by exploring the design strategies of advanced stimuli-responsive nanozymes (including types responsive to pH, glucose, enzyme, light, ultrasound, and magnetic fields), providing a comprehensive analysis of their underlying mechanisms, while highlighting their application progress across diverse wound types. Furthermore, this paper provides a forward-looking perspective on the future development of stimuli-responsive nanozymes.