Evidence-Based Guidelines for Drug Interaction Studies: Model-Informed Time Course of Intestinal and Hepatic CYP3A4 Inhibition by Clarithromycin
Asha J. Kapetas, Ahmad Y. Abuhelwa, Michael J. Sorich, Ross A. McKinnon, A. David Rodrigues, Andrew Rowland, Ashley M. Hopkins
Topics & Concepts
CYP3A4ClarithromycinPharmacologyDosingPharmacokineticsPopulationMedicineInternal medicineCytochrome P450MetabolismHelicobacter pyloriEnvironmental healthPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsAntibiotics Pharmacokinetics and Efficacy