Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain
Dillon Mintoff, Rachel Agius, Farida Benhadou, Anupam Das, John W. Frew, Nikolai Paul Pace
Abstract
Hidradenitis suppurativa (HS) is a chronic, inflammatory condition of the pilosebaceous unit. The typical patient with HS is characterized as someone with obesity, who smokes and who has nodules, abscesses and/or draining tunnels predominantly distributed in intertriginous skin. It has been established that lifestyle and genetic factors are the main pathophysiological drivers of HS. In this critical review, we explore the interrelatedness of meta-inflammation, obesity and HS and discuss if and how this relationship may be manipulated for a therapeutic end.
Topics & Concepts
Hidradenitis suppurativaIntertriginousMedicineObesityInflammationDermatologyMeta-analysisBioinformaticsInternal medicineDiseaseBiologyHidradenitis Suppurativa and TreatmentsColorectal and Anal CarcinomasMicroscopic Colitis