Multicomponent Assembly of Trisubstituted Imidazoles and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds
Diana Gapanenok, Azat Makhmet, Anatoly A. Peshkov, Darya Smirnova, Niyaz Amire, Vsevolod A. Peshkov, Dar’ya V. Spiridonova, Dmitry Dar’in, Saeed Balalaie, Mikhail Krasavin
Abstract
A straightforward route to a large and diverse library of trisubstituted imidazoles was established via a three-component reaction of 2-oxoaldehydes, 1,3-dicarbonyl compounds, and acyclic nitrogen bis-nucleophiles. The obtained products were subsequently explored in a photochemical cyclization yielding a variety of imidazole-fused polycyclic compounds.
Topics & Concepts
ChemistryImidazoleNucleophileCombinatorial chemistryComponent (thermodynamics)Organic chemistryCatalysisThermodynamicsPhysicsMulticomponent Synthesis of HeterocyclesCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis