Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease
Simon C. Johnson, Ernst‐Bernhard Kayser, Rebecca Bornstein, Julia Stokes, Alessandro Bitto, Kyung Yeon Park, Amanda Pan, Grace X Sun, Daniel Raftery, Matt Kaeberlein, Margaret M. Sedensky, Philip G. Morgan
Topics & Concepts
BiologyGlutamatergicNeurodegenerationGlutamate receptorPI3K/AKT/mTOR pathwayKnockout mouseGlutamineMitochondrionCitric acid cycleCell biologyMetabolismBiochemistryInternal medicineSignal transductionMedicineAmino acidDiseaseReceptorMitochondrial Function and PathologyATP Synthase and ATPases ResearchMetabolism and Genetic Disorders