A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
Poonam Dhindwal, Charis Thompson, Daniël Kos, Koa Planedin, Richa Jain, Murray Jelinski, Antonio C. Ruzzini
Abstract
The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.
Topics & Concepts
EsteraseBiologyGeneSerineSerine hydrolaseAntibiotic resistanceAntimicrobialIdentification (biology)MicrobiologyMicrobiomeComputational biologyGeneticsBiochemistryEnzymeAntibioticsBotanyAntibiotic Resistance in BacteriaAntimicrobial Peptides and ActivitiesBacteriophages and microbial interactions