Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs
Sarah A. Stewart, Juan Domínguez‐Robles, Victoria J. McIlorum, Z. González, Emilia Utomo, Elena Mancuso, Dimitrios A. Lamprou, Ryan F. Donnelly, Eneko Larrañeta
Abstract
release rates for hydrophilic model compounds (methylene blue and ibuprofen sodium) ranging from 0.01 to 34.09 mg/day, depending on the drug used. The versatility of the devices produced in this work and the range of release rates achievable show great potential. Implants could be specifically developed in order to match the specific release rate required for a number of drugs for a wide range of conditions.
Topics & Concepts
Caprolactone3d printedDrug deliveryChemistryNanotechnologyMaterials scienceBiomedical engineeringMedicineOrganic chemistryPolymerCopolymerbiodegradable polymer synthesis and propertiesBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications