Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit
Sihan Wang, Zhimin Ying, Youchun Huang, Yuting Li, Menglong Hu, Ke Won Kang, Haiyang Wang, Jiaan Shao, Gaoqi Wu, Yongping Yu, Yushen Du, Wenteng Chen
Topics & Concepts
ChemistryAmino acidMoietyProtein subunitDruggabilityOseltamivirSide chainIC50BiochemistryStereochemistryIn vitroGeneCoronavirus disease 2019 (COVID-19)DiseasePolymerInfectious disease (medical specialty)PathologyMedicineOrganic chemistryInfluenza Virus Research StudiesRespiratory viral infections researchRNA and protein synthesis mechanisms