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Computational tools for the prediction of site- and regioselectivity of organic reactions

Lukas M. Sigmund, Michele Assante, Magnus J. Johansson, Per‐Ola Norrby, Kjell Jorner, Mikhail Kabeshov

2025Chemical Science26 citationsDOIOpen Access PDF

Abstract

This article reviews computational tools for the prediction of the regio- and site-selectivity of organic reactions. It spans from quantum chemical procedures to deep learning models and showcases the application of the presented tools.

Topics & Concepts

RegioselectivityComputer scienceComputational chemistryChemistryCombinatorial chemistryOrganic chemistryCatalysisComputational Drug Discovery MethodsMachine Learning in Materials ScienceChemical Synthesis and Analysis
Computational tools for the prediction of site- and regioselectivity of organic reactions | Litcius