NGF nanoparticles enhance the potency of transplanted human umbilical cord mesenchymal stem cells for myocardial repair
Wei Luo, Yanshan Gong, Fan Qiu, Yi Yuan, Wenwen Jia, Zhongmin Liu, Ling Gao
Abstract
NGF PLGA nanoparticles can exert a protective effect on hUCMSCs and promote the paracrine effects of hUCMSCs on angiogenesis and cardiomyocyte protection through TrkA-PI3K/Akt signaling pathway, the same with free NGF. The application of NGF PLGA nanoparticles in the hUCMSC fibrin cardiac patches can significantly improve the retention of transplanted hUCMSCs and enhance their ability to reduce myocardial apoptosis and promote angiogenesis in the mouse heart after MI.
Topics & Concepts
Mesenchymal stem cellUmbilical cordPotencyStem cellCell biologyMedicineAndrologyChemistryInternal medicineBiologyImmunologyIn vitroBiochemistryNerve injury and regenerationElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative Medicine