Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1
Hedong Liu, Maoxian Ren, Yang Li, Ruotian Zhang, Nengfeng Ma, Tianlin Li, Wenkai Jiang, Zhi Zhou, Xuewei Yao, Zhiyi Liu, Min Yang
Abstract
experiments confirmed that melatonin improves the microstructure and bone mineral density of the distal femoral bone trabecula and promotes bone formation. Meanwhile, melatonin activated SIRT1, inhibited p66Shc and increased SIRT3 expression. Taken together, our findings showed that melatonin can restrain oxidative damage in MC3T3-E1 cells and promote osteogenesis by activating SIRT1 which regulate the activity of SIRT3 and inhibit the expression of p66Shc, suggesting that melatonin could be a potential therapeutic agent for osteoporosis-related bone metabolic diseases.
Topics & Concepts
MelatoninOxidative stressChemistryInternal medicineEndocrinologySuperoxide dismutaseOsteoporosisOsteoblastReactive oxygen speciesRUNX2SIRT3Cell biologyBiochemistryIn vitroBiologySirtuinMedicineNAD+ kinaseEnzymeCircadian rhythm and melatoninGenomics, phytochemicals, and oxidative stressTryptophan and brain disorders