Screening of an FDA-approved compound library identifies apigenin for the treatment of myocardial injury
Haixia Li, Dong Chen, Xiaoqin Zhang, Mingxian Chen, Yinghao Zhi, Weilu Cui, Shanshan Li, Fan Xu, Ying Tan, Hao Zhou, Xing Chang, Hengwen Chen
Abstract
via regulation of the Sirt1/Atf5 pathway. Our findings uncover that apigenin seems to be an effective therapeutic agent to alleviate Dox-mediated cardiotoxicity.
Topics & Concepts
ApigeninPharmacologyGene knockdownCardiotoxicityChemistryApoptosisMedicineAntioxidantBiochemistryInternal medicineToxicityFlavonoidMitochondrial Function and PathologyATP Synthase and ATPases ResearchAutophagy in Disease and Therapy