Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy
Weixin Chen, Jia Ming Nickolas Teo, Siu Wah Yau, Melody Yee‐Man Wong, Chun‐Nam Lok, Chi‐Ming Che, Asif Javed, Yuanhua Huang, Stephanie Ma, Guang Sheng Ling
Abstract
TIL exhaustion and has important implications for immunotherapy.
Topics & Concepts
CD8Lipid peroxidationCancer researchImmunotherapyImmune systemCytotoxic T cellT cellCell biologyBlockadeOxidative stressInterferonLipid metabolismCancer immunotherapyBiologyImmunologySignal transductionReceptorEndocrinologyBiochemistryIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers