DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair
Ye-Rim Lee, Gi-Sue Kang, Taerim Oh, Hye-Ju Jo, Hye-Joon Park, G‐One Ahn
Abstract
knockout. Moreover, while there are several DNA-PK inhibitors currently being evaluated in the clinical trials in attempt to increase the efficacy of radiotherapy or chemotherapy, multiple functions and subcellular localization of DNA-PKcs in various types of cells may further complicate the effects at the cellular and organismal level.
Topics & Concepts
DNA-PKcsDNA repairCell biologyProtein subunitHomologous recombinationDNANon-homologous end joiningBiologyDNA repair protein XRCC4Molecular biologyV(D)J recombinationChemistryGeneticsGeneRecombinationNucleotide excision repairCytomegalovirus and herpesvirus researchDNA Repair MechanismsCRISPR and Genetic Engineering