The protective effect of <scp>l</scp>-theanine on the intestinal barrier in heat-stressed organisms
Bin Wang, Sha Liu, Ling Lin, Wei Xu, Zhihua Gong, Wenjun Xiao
Abstract
in the intestinal tract of heat-stressed organisms and restored gut microbiota homeostasis. LTA promoted the secretion of IL-4, IL-10, and sIgA and inhibited the secretion of TNF-α and IFN-γ in the colon of heat-stressed organisms. The expressions of Hsf1, Hsp70, Hsph1, TLR4, P38 MAPK, p-P65 NF-κB, MLCK mRNA, and proteins were downregulated by LTA in the colon of heat-stressed organisms. These results suggest that LTA protects the intestinal barrier in heat-stressed organisms by modulating multiple molecular pathways. Therefore, this study provides evidence on how tea-containing LTA treatments could be used to prevent and relieve intestinal problems related to heat stress.
Topics & Concepts
ChemistryFood scienceCell biologyBiologyGut microbiota and healthExercise and Physiological ResponsesMeat and Animal Product Quality