Facial Skin Microbiota-Mediated Host Response to Pollution Stress Revealed by Microbiome Networks of Individual
Lu Wang, Yining Xu, Chung-Ching Chu, Zehua Jing, Yabin Chen, Jingsong Zhang, Mingming Pu, Tingyan Mi, Yaping Du, Zong-Qi Liang, Chandraprabha Doraiswamy, Tao Zeng, Jiarui Wu, Luonan Chen
Abstract
The association between the skin microbiome and skin health has been widely reported. However, the role of the skin microbiome in mediating skin physiology remains a challenging and yet priority subject in the field. Through developing a novel MNI method followed by mediation analysis, we characterized the network signature of the skin microbiome at an individual level and revealed the role of the skin microbiome in mediating the skin's responses toward environmental stressors. Our findings may shed new light on microbiome functions in skin health and lay the foundation for the design of a microbiome-based intervention strategy in the future.