Mechanisms that limit regression of myocardial fibrosis following removal of left ventricular pressure overload
Lily S. Neff, Yuhua Zhang, An O. Van Laer, Catalin F. Baicu, Mark P. Karavan, Michael R. Zile, Amy D. Bradshaw
Abstract
In this study, a murine model demonstrated persistent interstitial fibrosis and myocardial stiffness following alleviation of pressure overload.
Topics & Concepts
Pressure overloadFibrosisExtracellular matrixInternal medicineVolume overloadEndocrinologyMyocardial fibrosisCollagenaseHemodynamicsChemistryMedicineCardiologyHeart failureEnzymeBiochemistryCardiac hypertrophyCardiac Fibrosis and RemodelingTissue Engineering and Regenerative MedicineCardiac Valve Diseases and Treatments