Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex
James Chen, Qi Wang, Brandon Malone, Eliza Llewellyn, Yakov Pechersky, Kashyap Maruthi, Edward T. Eng, Jason K. Perry, Elizabeth A. Campbell, David E. Shaw, Seth A. Darst
Topics & Concepts
HelicaseRNA polymeraseRNA Helicase ATranscription (linguistics)RNARNA-dependent RNA polymeraseBiologyProcessivityAllosteric regulationPolymeraseGeneticsTranscription preinitiation complexCell biologyDNAPromoterGeneGene expressionReceptorLinguisticsPhilosophyViral gastroenteritis research and epidemiologyViral Infections and Immunology ResearchRNA Research and Splicing