Evaluation of HRR (Hemoglobin/Red Blood Cell Distribution Width Ratio) and RAR (Red Blood Cell Distribution Width/Albumin Ratio) in Myocarditis Patients: Associations with Various Clinical Parameters
Azmi Eyiol, Hatice Eyiol, Ahmet Taha Şahin
Abstract
Aim: This study investigates the prognostic value of the Hemoglobin/Red Blood Cell Distribution Width Ratio (HRR) and the Red Blood Cell Distribution Width/Albumin Ratio (RAR) in patients with myocarditis. We aimed to evaluate how these novel biomarkers correlate with clinical parameters, disease severity, and outcomes. Methods: A retrospective analysis was conducted on 301 patients diagnosed with myocarditis between January 2020 and March 2024. Inclusion criteria were adults with confirmed myocarditis based on clinical, ECG and echocardiographic evaluations. Exclusion criteria included incomplete records and prior immunosuppressive therapy. We assessed various blood parameters, including HRR and RAR, and analyzed their associations with clinical outcomes, hospital stay duration, and complications. Results: The study found that HRR and RAR were significantly associated with several clinical outcomes in myocarditis patients. Higher HRR values correlated with improved outcomes, while higher RAR values were linked to worse outcomes. HRR was associated with pericardial effusion, inotropic support, and other parameters, while RAR was correlated with similar factors, including recent gastroenteritis. Patients with longer hospital stays exhibited higher inflammation markers and lower ejection fractions, underscoring the severity of their condition. Conclusion: HRR and RAR are promising biomarkers for assessing disease severity and prognosis in myocarditis. They provide additional prognostic information beyond traditional markers such as troponin and CRP, potentially guiding more personalized treatment strategies.