Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells
Marcia A. Ciccone, Crystal L. Adams, Charles M. Bowen, Teena Thakur, Charité Ricker, Julie O. Culver, Asaf Maoz, Marilena Melas, Gregory Idos, Anand D. Jeyasekharan, Koji Matsuo, Lynda D. Roman, Stephen B. Gruber, Kevin McDonnell
Topics & Concepts
OlaparibSynthetic lethalityCarboplatinCancer researchOvarian cancerMedicineCisplatinDNA damagePARP inhibitorDNA repairCancerBiologyPoly ADP ribose polymeraseInternal medicineGeneticsGenePolymeraseChemotherapyDNAPARP inhibition in cancer therapyBRCA gene mutations in cancerDNA Repair Mechanisms