Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation
Wanghui Jing, Sijing Dong, Yinyue Xu, Jingjing Liu, Jiawei Ren, Xue Liu, Min Zhu, M Zhang, Hehe Shi, Na Li, Peng Xia, Haitao Lu, Sicen Wang
Abstract
-IAA-AhR signaling pathway. This study provides novel insights into colitis pathogenesis and presents an effective therapeutic and preventive approach against IBD.
Topics & Concepts
Gut floraColitisTryptophanSignal transductionMedicineChemistryPharmacologyInternal medicineBiochemistryImmunologyAmino acidGut microbiota and healthPharmacological Effects of Natural CompoundsGastrointestinal motility and disorders