TCP1 regulates Wnt7b/β-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells
Nanhong Tang, Xiaoling Cai, Lirong Peng, Hekun Liu, Yuanzhong Chen
Abstract
Molecular chaperones are critical mediators of oncogenesis and necessary for cell survival. The cytoplasmic chaperone TRiC (Tcomplex protein-1 ring complex, also known as CCT) comprises two back-to-back stacked rings, with each ring containing eight subunits (CCT1-CCT8). 2 And the effects of CCT subunits on tumors may be different. However, the roles of the CCT1 subunit (also known as TCP1) in hepatocellular carcinoma (HCC) and its molecular mechanism have not been investigated thoroughly. Understanding these details can provide new ideas and strategies for treating HCC.
Topics & Concepts
Hepatocellular carcinomaCancer researchCateninChemistrySignal transductionCell biologyBiologyWnt signaling pathwayEndoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathwaysCancer, Hypoxia, and Metabolism