Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
Julia A. Belk, Winnie Yao, Nghi Ly, Katherine A. Freitas, Yanting Chen, Quanming Shi, Alfredo M. Valencia, Eric Shifrut, Nupura Kale, Kathryn E. Yost, Connor V. Duffy, Bence Dániel, Madeline A. Hwee, Zhuang Miao, Alan Ashworth, Crystal L. Mackall, Alexander Marson, Julia Carnevale, Santosha A. Vardhana, Ansuman T. Satpathy
Topics & Concepts
CRISPRPersistence (discontinuity)ChromatinBiologyGenomeCellChromatin remodelingGeneticsComputational biologyLimit (mathematics)Cell biologyGeneMathematical analysisMathematicsGeotechnical engineeringEngineeringCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology