Litcius/Paper detail

IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis

Yilin Chen, Beian Lin, Shiyu Yang, Jingshan Huang

2023Experimental Cell Research22 citationsDOI

Topics & Concepts

BiologyIRF1Transcription factorCell biologyCancer researchGPX4Cancer cellTranscriptional regulationCancerGeneticsGeneOxidative stressBiochemistryCatalaseGlutathione peroxidaseFerroptosis and cancer prognosisCancer-related molecular mechanisms researchCancer, Lipids, and Metabolism