The Composition of Intestinal Microbiota and its Association with Functional Constipation of the Elderly Patients
Mingquan Guo, Jianfeng Yao, Feng Yang, Wenjian Liu, Huijing Bai, Jianxia Ma, Xingchen Ma, Jinghao Zhang, Yi Fang, Yingxin Miao, Jianqin Sun, Yanmei Zhang, Hu Zhao
Abstract
Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were significantly different from healthy controls. Additionally, the species diversity of healthy controls was greater than that of FC patients. Indeed, the abundance of Firmicutes and Proteobacteria was significantly decreased, whereas that of Bacteroides, Prevotella, Lactococcus, Ruminococcus and Butyricimonas was remarkably increased in FC patients. Conclusion: Elderly FC patients appear to have a unique intestinal microbiota profile. Our findings should provide insight regarding the pathogenic mechanism of FC and evidence for exploring new therapeutic strategies in elderly FC patients.