Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
Arianna Fumagalli, Koen C. Oost, Lennart Kester, Jessica Morgner, Laura Bornes, Lotte Bruens, Lisa Spaargaren, Maria Azkanaz, Tim Schelfhorst, Evelyne Beerling, Maria C. Heinz, Daniel Postrach, Daniëlle Seinstra, Anieta M. Sieuwerts, John W.M. Martens, Stefan van der Elst, Martijn v. Baalen, Debajit Bhowmick, Nienke Vrisekoop, Saskia I. J. Ellenbroek, Saskia J.E. Suijkerbuijk, Hugo J.G. Snippert, Jacco van Rheenen
Abstract
cells, which display intrinsic capacity to become CSCs in a niche-independent manner and can restore epithelial hierarchies in metastatic tumors.
Topics & Concepts
LGR5Colorectal cancerBiologyMetastasisCancer stem cellStem cellCancer researchCancerCancer cellImmunologyCell biologyGeneticsCancer Cells and MetastasisHippo pathway signaling and YAP/TAZFOXO transcription factor regulation