15-keto-PGE2 alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors
Siow‐Wey Hee, Yi‐Cheng Chang, Lynn Su, Ing‐Jung Chen, Yung‐Ming Jeng, Meng-Lun Hsieh, Yu-Chia Chang, Fu‐An Li, Daniel Liao, Shiau-Mei Chen, Lee‐Ming Chuang
Abstract
, through NF-κB modification, in preventing the development and progression of steatohepatitis, emphasizing the significance of endogenous lipid mediators in the inflammatory response.
Topics & Concepts
LipogenesisSteatohepatitisChemistryInflammationAspartate transaminaseAlanine transaminaseNF-κBEndocrinologyInternal medicineNonalcoholic steatohepatitisBiochemistrySignal transductionLipid metabolismFatty liverBiologyAlkaline phosphataseEnzymeMedicineNonalcoholic fatty liver diseaseDiseaseLiver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated ReceptorsDiet, Metabolism, and Disease